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林云 实验员、博士。
主持浙江省自然科学基金等项目6项;近年发表论文和专利共计10余篇。
主要研究领域
(一)有机化学方向
(1)Diversity-Oriented synthesis of Bioactive Heterocyclics;
(2)Ruthenium(II)-Catalyzed Synthesis of Hydroxylated Arenes;
(二)药物设计与合成方向
(1)Synthesis of probes for BRD7 research Participate in the design of probes for BRD7 research;
(2)Hydrazine-Sensitive Thiol Protecting Group for Peptide and Protein Chemistry。
主持主要科研项目
(1)省基金项目:含吡啶稠杂环药物骨架的快速合成及修饰,总经费30万
(2)横向项目:一种4-氟-4-甲基环己醇的合成方法,在研
(3)横向项目:一种3-溴-6-异丙基-1氢-哌咯[2,3-b]并吡啶的合成方法,在研
(4)横向项目:一种咪唑并[1,2-B]-[1,2,4]三嗪-2-基苯甲酰胺抑制剂的合成路线研,在研
代表性成果
(1)Y. Yang, Y. Lin, and Y. Rao.* Ruthenium(II)-Catalyzed Synthesis of Hydroxylated Arenes with Ester as an Effective Directing Group. Org. Lett. 2012, 14, 2874-2877.
(2)Y. Lin, L. Zhu, Y. Lan* and Y. Rao.* "Development of Rhodium(II)-Catalyzed Chemoselective C(SP3)-H Oxygenation". Chem. Eur. J., 2015, 21, 118.
(3)Y. Lin, X. Yang, W. Pan* and Yu Rao.* "One-Step Synthesis of Diverse Pyridine-Containing Heterocycles with 3‑Ethoxycyclobutanones at Room Temperature". Org. Lett. In press. DOI: http://dx.doi.org/10.1021/acs.orglett.6b01027
(4)林云等。一种3-[(4-磺胺哌嗪-1-基)甲基]苯甲酸类化合物的制备方法.授权号:202211515248.2
联系方式
E-mail:linyun{at}nit.zju.edu.cn